Drug Standards
AdipoGen Ketoconazole
Chemical. CAS 65277-42-1. Formula C26H28Cl2N4O4. MW 531.43. Ketoconazole is a broad-spectrum triazole antifungal agent that has activity against C. albicans, C. krusei, C. tropicalis, C. glabrata, C. parapsilosis, C. neoformans and A. fumigatus strains IC50s = 0.031-8 µg/ml. It inhibits the fungal cytochrome P450 CYP isoform CYP51, also known as lanosterol 14alpha-demethylase, which arrests ergosterol biosynthesis at the fungal membrane. This interaction inhibits ergosterol synthesis and results in increased fungal cellular permeability. Ketoconazole also inhibits human CYP3A4 IC50 = 0.54 µM. Formulations containing ketoconazole have been used in the treatment of fungal infections. Ketoconazole blocks in humans activity of several enzymes necessary for the conversion of cholesterol to steroid hormones such as testosterone and cortisol.
Sigma Aldrich Fine Chemicals Biosciences Acemetacin European Pharmacopoeia (EP) Reference Standard | 53164-05-9 | MFCD00151473 |
Acemetacin European Pharmacopoeia (EP) Reference Standard | Mol Wt: 415.82 | 53164-05-9 | MFCD00151473 |
Medchemexpress LLC Larotrectinib | 1223403-58-4 | 99.9% | 10 MG
Larotrectinib is an ATP-competitive oral, selective inhibitor of the tropomyosin-related kinase (TRK) family receptors. It demonstrates low nanomolar 50% inhibitory concentrations against all three isoforms (TRKA, B, and C) and exhibits 1,000-fold or greater selectivity relative to other kinases. This product is for research use only.
- Targets TrkA, TrkB, and TrkC
- Exhibits antiproliferative activity against various cell lines
- Demonstrates dose-dependent inhibition of cell proliferation
- Has low brain penetration in animal studies
- Well tolerated in GLP toxicology studies
- Reduces tyrosine phosphorylation of TRKA and downstream signal transduction in tumors
- Shows dose-dependent tumor inhibition in athymic nude mice
- Reduces leukemic infiltration in bone marrow and spleen in mice
Sigma Aldrich Fine Chemicals Biosciences 1-Pentan-d11-ol 98 atom % D | 126840-22-0 | MFCD00145002 | 5G
1-Pentan-d11-ol 98 atom % D | Purity: 99% (CP) | Mol Wt: 99.22 | 126840-22-0 | MFCD00145002 | 5G
Sigma Aldrich Fine Chemicals Biosciences Terbinafine hydrochloride United States Pharmacopeia (USP) Reference Standard | 78628-80-5 | MFCD00145430 | 200MG
Terbinafine hydrochloride United States Pharmacopeia (USP) Reference Standard | Mol Wt: 327.89 | 78628-80-5 | MFCD00145430 | 200MG
Sigma Aldrich Fine Chemicals Biosciences (-)-Catechin gallate >=98% (HPLC), from green tea | 130405-40-2 | MFCD00214258 | 1MG
(-)-Catechin gallate >=98% (HPLC), from green tea | Purity: >=98% (HPLC) | Mol Wt: 442.37 | 130405-40-2 | MFCD00214258 | 1MG
Sigma Aldrich Fine Chemicals Biosciences Terbinafine hydrochloride British Pharmacopoeia (BP) Reference Standard | 78628-80-5 | MFCD00145430 |
Terbinafine hydrochloride British Pharmacopoeia (BP) Reference Standard | Mol Wt: 327.89 | 78628-80-5 | MFCD00145430 |
Medchemexpress LLC (3S,4S)-Tofacitinib | 1092578-47-6 | MFCD11035920 | 99.8% | 312.37 g/mol | C16H20N6O | 10 MG
(3S,4S)-Tofacitinib is the S-enantiomer of the JAK inhibitor tofacitinib and is provided as a research reference compound for biochemical and cellular studies. It is reported to be less active than the clinical racemate and is characterized by CAS 1092578-47-6, formula C16H20N6O, and molecular weight 312.37 g/mol.
- Enantiomeric reference for JAK signaling studies.
- High purity (99.75%) suitable for analytical and biochemical assays.
- Molecular formula C16H20N6O and molecular weight 312.37 g/mol.
- Supplied as a 10 mg research quantity.
- Useful as a reference standard for selectivity and potency comparisons.
Sigma Aldrich Fine Chemicals Biosciences Sesame Oil Related Compound B United States Pharmacopeia (USP) Reference Standard | 2190-15-0 | MFCD00214267 | 2X12MG
Sesame Oil Related Compound B United States Pharmacopeia (USP) Reference Standard | Mol Wt: 855.36 | 2190-15-0 | MFCD00214267 | 2X12MG
Medchemexpress LLC Bromfenac sodium hydrate | 120638-55-3 | 99.9% | 200 MG
Bromfenac sodium hydrate is a potent and orally active inhibitor of COX, with IC50s of 5.56 and 7.45 nM for COX-1 and COX-2, respectively. It can be used in ocular inflammation research.
- Potent and orally active inhibitor of COX.
- Can be used in ocular inflammation research.
- Available in solid and solution forms.
Medchemexpress LLC Ethyl linolenate | 1191-41-9 | 306.48 | 500 MG
Ethyl linolenate is a fatty acid ethyl ester (FAEE) that inhibits the cellular production of melanin with an IC50 of 70 μM, demonstrating anti-melanogenesis effects. It significantly blocks Forskolin-induced melanogenesis and inhibits tyrosinase activity. This product is for research use only.
- Fatty acid ethyl ester (FAEE)
- Inhibits cellular production of melanin with an IC50 of 70 μM
- Anti-melanogenesis effects
- Significantly blocks Forskolin-induced melanogenesis
- Inhibits tyrosinase activity
- Purity: 98.0%
Medchemexpress LLC Spironolactone | 52-01-7 | MFCD00082250 | 98.6% | 416.57 g/mol | C24H32O4S | 10 MG
Spironolactone analytical reference standard intended for research and analytical applications, including qualitative and quantitative methods (HPLC, GC, MS). The product is supplied as a small-quantity solid with high stated purity to support accurate assay performance.
- Analytical/reference standard suitable for HPLC, GC, and MS.
- High stated purity (98.6%), supporting accurate quantitative results.
- Molecular weight 416.57 g/mol for mass identification.
- CAS number 52-01-7 for unambiguous compound identification.
- Supplied in a 10 mg quantity for analytical and method development use.
Medchemexpress LLC Benzoic acid, 3,4,5-trihydroxy-, propyl ester | 121-79-9 | MFCD00002196 | 100.0% | 212.20 | C10H12O5 | 10 MG
Propyl gallate (CAS 121-79-9) is an analytical reference standard of the antioxidant propyl gallate, supplied as a solid, white to off-white powder for research and analytical applications. It is used for calibration, method validation, and as a reference material in quantitative assays.
- Analytical standard for calibration and method validation.
- High purity suitable for quantitative analysis.
- Solid, white to off-white form for straightforward handling.
- Available in small 10 mg quantities for analytical workflows.
- Includes documentation such as certificate of analysis and safety data sheet for traceability.
Medchemexpress LLC Voriconazole | 137234-62-9 | MFCD00905717 | 99.9% | 349.31 g/mol | C16H14F3N5O | 10 MG
Voriconazole analytical standard is a second-generation, broad-spectrum triazole antifungal provided as a high-purity reference material for research and analytical testing. It is intended for use in HPLC and other analytical assays to support quantitation and method validation.
- Analytical standard for research and analytical applications.
- High purity (99.9%).
- Molecular formula C16H14F3N5O.
- Molecular weight 349.31 g/mol.
- CAS number 137234-62-9.
- Supplied in small pack sizes suitable for analytical use, e.g., 10 mg.
- Antifungal mechanism: inhibits 14-α-lanosterol demethylation.